The recent find of a San Patrice projectile point at the Dimond Knoll site nearby on Cypress Creek attests to a human presence in the area by 7500 BC. By the early historic era, the area around present-day Cypress was populated by Atakapa and Akokisa Indian tribes, but they soon disappeared after the appearance of German settlers in the 1840s.

The German heritage is most notably reflected in the names of some of the major thoroughfares of the area, such as Huffmeister and Telge Roads. General Sam Houston and his Texas Army camped in the area on March 22, 1836 on the way to Harrisburg, which is now in East Houston, just days before the Battle of San Jacinto.

The area remained mostly rural until the early 1990s when developers began construction of several master-planned communities. The area is often referred to as Cy-Fair or Cypress-Fairbanks, which comes from when the Big Cypress School and Fairbanks High School combined in the 1930s to form Cy-Fair High School and the Cypress-Fairbanks Independent School District. In March 2008, the Cypress Historical Society (CHS) was formed as a non-profit corporation with its primary mission being “…to discover, educate, promote, collect, preserve and make available to the public, historical documents and artifacts of the Cypress area”. The CHS organization holds regular events aimed at exposing Cypress‘ residents to the historical and cultural foundation upon which the area was built.